Atp2b2 Gene Summary [Mouse]
Enables calcium-dependent ATPase activity. Involved in calcium ion transport; cochlea development; and regulation of cytosolic calcium ion concentration. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of sound; lactation; and neuron differentiation. Located in several cellular components, including apical plasma membrane; endoplasmic reticulum; and neuronal cell body. Is active in glutamatergic synapse; photoreceptor ribbon synapse; and presynaptic membrane. Is expressed in heart; labyrinthine zone; liver; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 82 and autosomal recessive nonsyndromic deafness 12. Orthologous to human ATP2B2 (ATPase plasma membrane Ca2+ transporting 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp2b2 |
| Official Name | ATPase, Ca++ transporting, plasma membrane 2 [Source:MGI Symbol;Acc:MGI:105368] |
| Ensembl ID | ENSMUSG00000030302 |
| Bio databases IDs | |
| Aliases | ATPase, Ca++ transporting, plasma membrane 2 |
| Synonyms | ATPase, Ca++ transporting, plasma membrane 2, ATPase plasma membrane Ca2+ transporting 2, D6Abb2e, DFNA82, dfw, Gena300, jog, Plasma membrane calcium transporting atpase 2, PMCA2, Pmca2b, Tmy, wms, wri |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp2b2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cation transporter/ATPase, N-terminus
- regulatory domain
- sarco/endoplasmic reticulum calcium-translocating P-type ATPase
- ATP binding
- heavy metal translocating P-type ATPase
- E1-E2 ATPase
- copper-(or silver)-translocating P-type ATPase
- plasma-membrane calcium-translocating P-type ATPase
- phospholipid-translocating P-type ATPase, flippase
- Na,H/K antiporter P-type ATPase alpha subunit
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Cation transport ATPase (P-type)
- Cation transporting ATPase, C-terminus
- Ca2+-transporting ATPase
- calmodulin binding
- heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase
- calcium ion binding
- protein binding
- receptor binding
- P-type ATPase of unknown pump specificity (type V)
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- Plasma membrane calcium transporter ATPase C terminal
- PDZ-domain binding
- K+-transporting ATPase, B subunit
- PDZ binding motif
- Haloacid Dehalogenase-like Hydrolases
- transporter
Pathways
Biological processes and signaling networks where the Atp2b2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- Waldenström macroglobulinemia
- sporadic amyotrophic lateral sclerosis
- breast cancer
- insomnia
- epithelial cancer
- Huntington disease
- bipolar disorder
- age-related hearing loss
- sensorineural hearing loss
role in cell
- expression in
- number
- phosphorylation in
- apoptosis
- activity
- loss
- differentiation
- morphology
- engulfment
- lack
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cilia
- cellular membrane
- Endoplasmic Reticulum
- actin bundles
- stereocilia
- microsome
- apical membrane
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- basolateral membrane
- dendritic spines
- neurites
- synapse
- cuticular plate
- perikaryon
- dendrites
- ribbon synapse
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp2b2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- neuron differentiation
- ion transmembrane transport
- neural retina development
- calcium ion transport
- calcium ion transmembrane transport
- cytosolic calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- dendritic spine membrane
- intracellular membrane-bounded organelle
- neuronal cell body membrane
- presynaptic active zone membrane
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- glutamate receptor binding
- calmodulin binding
- protein binding
- metal ion binding
- PDZ domain binding
- calcium-transporting ATPase activity