DHRS9 Gene Summary [Human]
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. This protein demonstrates oxidoreductase activity toward hydroxysteroids and is able to convert 3-alpha-tetrahydroprogesterone to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone in the cytoplasm, and may additionally function as a transcriptional repressor in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Details
| Type | Protein Coding |
| Official Symbol | DHRS9 |
| Official Name | dehydrogenase/reductase 9 [Source:HGNC Symbol;Acc:HGNC:16888] |
| Ensembl ID | ENSG00000073737 |
| Bio databases IDs | |
| Aliases | dehydrogenase/reductase 9, NADP-dependent retinol dehydrogenase/reductase, 3-alpha hydroxysteroid dehydrogenase, retinol dehydrogenase homolog, short chain dehydrogenase/reductase family 9C, member 4 |
| Synonyms | 3ALPHA-HSD, 3-α-HSD, C730025I08Rik, dehydrogenase/reductase 9, Eroldh, hRoDH-E2, NOVEL type MICROSOMAL 3alpha-HSD, RDH15, RDHL, RDH-TBE, RETSDR8, SDR9C4, Similar to alcohol dehydrogenase pan1b-like |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DHRS9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADP-retinol dehydrogenase
- alcohol dehydrogenase
- Rossmann-fold NAD(P)(+)-binding proteins
- 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD)
- 3alpha(or 20beta)-hydroxysteroid dehydrogenase
- retinol dehydrogenase
- 3(or 17)alpha-hydroxysteroid dehydrogenase
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the DHRS9 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- atrial fibrillation
- diabetes mellitus
- dextran sodium sulfate-induced colitis
- systemic sclerosis
- polycystic kidney disease
- lung cancer
- systemic lupus erythematosus
- colorectal cancer
- diabetic nephropathy
role in cell
- proliferation
- expression in
- colony formation by
- migration
- oxygen consumption rate
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- endoplasmic reticulum membrane
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DHRS9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- progesterone metabolic process
- androgen metabolic process
- 9-cis-retinoic acid biosynthetic process
- retinol metabolic process
- steroid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- racemase and epimerase activity
- androstan-3-alpha,17-beta-diol dehydrogenase activity
- retinol dehydrogenase activity
- testosterone dehydrogenase (NAD+) activity
- androsterone dehydrogenase activity
- alcohol dehydrogenase (NAD) activity