Elp4 Gene Summary [Mouse]
Predicted to enable phosphorylase kinase regulator activity. Predicted to contribute to RNA polymerase II complex binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II and tRNA wobble uridine modification. Predicted to be located in nucleoplasm. Predicted to be part of elongator holoenzyme complex and transcription elongation factor complex. Predicted to be active in cytoplasm. Is expressed in several structures, including eye and telencephalon. Human ortholog(s) of this gene implicated in aniridia. Orthologous to human ELP4 (elongator acetyltransferase complex subunit 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Elp4 |
| Official Name | elongator acetyltransferase complex subunit 4 [Source:MGI Symbol;Acc:MGI:1925016] |
| Ensembl ID | ENSMUSG00000027167 |
| Bio databases IDs | |
| Aliases | elongator acetyltransferase complex subunit 4 |
| Synonyms | A330107A17Rik, AN, AN2, C11orf19, dJ68P15A.1, elongator acetyltransferase complex subunit 4, hELP4, PAX6NEB, PAXNEB, RGD1566052 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Elp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PAXNEB protein
- phosphorylase kinase regulator
- enzyme binding
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- insomnia
- developmental delay, epilepsy, intellectual disability, and motor dysfunction
- neuroticism
- aniridia type 2
- idiopathic perifoveal telangiectasia
- aniridia
- glaucoma
regulated by
- methamphetamine
- HNRNPH1
regulates
- histone H4
- histone H3
- RNA polymerase II
- DNA promoter
- DNA endogenous promoter
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Elp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- tRNA wobble uridine modification
- transcription elongation from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription elongation factor complex
- cytoplasm
- Elongator holoenzyme complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphorylase kinase regulator activity
- protein binding
- RNA polymerase II core binding