Trim44 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of protein K48-linked ubiquitination; positive regulation of defense response to virus by host; and positive regulation of signal transduction. Predicted to be active in cytoplasm. Is expressed in central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in aniridia. Orthologous to human TRIM44 (tripartite motif containing 44). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim44 |
| Official Name | tripartite motif-containing 44 [Source:MGI Symbol;Acc:MGI:1931835] |
| Ensembl ID | ENSMUSG00000027189 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 44 |
| Synonyms | AN3, DIPB, HSA249128, MC7, tripartite motif-containing 44 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim44 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- B-box-type zinc finger superfamily
- B-box zinc finger
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- major depression
- aniridia type 3
- laryngeal squamous cell carcinoma
- squamous cell cancer of the larynx
- infection by HIV-1
role in cell
- expression in
- growth
- apoptosis
- cell viability
- deubiquitination in
- double-stranded DNA break repair in
- degradation in
- oligomerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim44 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cytokine-mediated signaling pathway
- positive regulation of transcription, DNA-dependent
- regulation of gene expression
- positive regulation of defense response to virus by host
- protein stabilization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding