Ell3 Gene Summary [Mouse]
Enables cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of epithelial to mesenchymal transition; and transcription by RNA polymerase II. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of cell population proliferation; and positive regulation of neurogenesis. Located in nucleus. Is expressed in embryo endoderm and olfactory epithelium. Orthologous to human ELL3 (elongation factor for RNA polymerase II 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ell3 |
| Official Name | elongation factor RNA polymerase II-like 3 [Source:MGI Symbol;Acc:MGI:2673679] |
| Ensembl ID | ENSMUSG00000027246 |
| Bio databases IDs | |
| Aliases | elongation factor RNA polymerase II-like 3 |
| Synonyms | A930015D22Rik, C80083, elongation factor for RNA polymerase II 3, elongation factor RNA polymerase II-like 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ell3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- Occludin homology domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- cytosol
- chromosome
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ell3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- neural precursor cell proliferation
- transcription elongation, DNA-dependent
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- transcription from RNA polymerase II promoter
- snRNA transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
- positive regulation of transcription elongation from RNA polymerase II promoter
- regulation of epithelial to mesenchymal transition
- stem cell differentiation
- positive regulation of stem cell proliferation
- stem cell proliferation
- positive regulation of neural precursor cell proliferation
- positive regulation of neurogenesis
- positive regulation of transcription elongation, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription elongation factor complex
- nuclear speck
- cytosol
- cell junction
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- core promoter proximal region sequence-specific DNA binding