Eaf2 Gene Summary [Mouse]
Predicted to enable transcription elongation factor activity. Acts upstream of or within negative regulation of cell growth; negative regulation of epithelial cell proliferation involved in prostate gland development; and positive regulation of DNA-templated transcription. Located in nucleoplasm. Is expressed in several structures, including genitourinary system; integumental system; nervous system; sensory organ; and tooth. Orthologous to human EAF2 (ELL associated factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eaf2 |
| Official Name | ELL associated factor 2 [Source:MGI Symbol;Acc:MGI:2146616] |
| Ensembl ID | ENSMUSG00000022838 |
| Bio databases IDs | |
| Aliases | ELL associated factor 2 |
| Synonyms | BM-040, ELL associated factor 2, Festa, FESTA-L, FESTA-S, TRAITS, U19 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eaf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
- RNA polymerase II transcription elongation factor
- transcriptional elongation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- non-small cell lung cancer
- cancer
- liver neoplasia
- lymphomagenesis
- B cell cancer
- B-cell neoplasia
- hematologic cancer
- lymphoid cancer
role in cell
- apoptosis
- proliferation
- expression in
- phosphorylation in
- accumulation in
- growth
- stabilization in
- migration
- invasion by
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eaf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epithelial cell proliferation involved in prostate gland development
- regulation of transcription elongation from RNA polymerase II promoter
- negative regulation of cell growth
- apoptotic process
- epithelial cell proliferation involved in prostate gland development
- positive regulation of transcription from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription elongation factor complex
- nuclear speck
- ELL-EAF complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription elongation regulator activity
- protein binding