Eaf1 Gene Summary [Mouse]
Predicted to enable transcription elongation factor activity. Predicted to be involved in regulation of transcription elongation by RNA polymerase II and transcription elongation by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in intercellular bridge and nuclear body. Predicted to be part of transcription elongation factor complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human EAF1 (ELL associated factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eaf1 |
| Official Name | ELL associated factor 1 [Source:MGI Symbol;Acc:MGI:1921677] |
| Ensembl ID | ENSMUSG00000021890 |
| Bio databases IDs | |
| Aliases | ELL associated factor 1 |
| Synonyms | 4933403C17Rik, ELL associated factor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eaf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription factor binding
- protein binding
- RNA polymerase II transcription elongation factor
- transcriptional elongation regulator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cytoplasmic bridges
- nucleoplasm
- nuclear bodies
- nuclear speckles
- Cajal bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eaf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription elongation from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- intercellular bridge
- nuclear body
- transcription elongation factor complex
- nuclear speck
- intracellular membrane-bounded organelle
- Cajal body
- ELL-EAF complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription elongation regulator activity
- protein binding