Hexim1 Gene Summary [Mouse]
Predicted to enable several functions, including 7SK snRNA binding activity; P-TEFb complex binding activity; and cyclin-dependent protein serine/threonine kinase inhibitor activity. Acts upstream of or within heart development and negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including branchial arch; embryo mesenchyme; heart and pericardium; hindgut dorsal mesentery; and sensory organ. Orthologous to human HEXIM1 (HEXIM P-TEFb complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hexim1 |
| Official Name | hexamethylene bis-acetamide inducible 1 [Source:MGI Symbol;Acc:MGI:2385923] |
| Ensembl ID | ENSMUSG00000048878 |
| Bio databases IDs | |
| Aliases | hexamethylene bis-acetamide inducible 1 |
| Synonyms | 7330426E13Rik, CLP-1, EDG1, hexamethylene bis-acetamide inducible 1, HEXIM P-TEFb complex subunit 1, HIS1, MAQ1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hexim1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase inhibitor activity
- snRNA binding
- transcription regulator
- binding protein
- protein kinase inhibitor activity
- nuclear localization sequence
- Hexamethylene bis-acetamide-inducible protein
- protein binding
- basic domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypoplasia
- metastasis
- fibrosis
- peripheral arterial disease
role in cell
- expression in
- apoptosis
- proliferation
- binding in
- recruitment in
- downregulation in
- differentiation
- recruitment
- cell cycle progression
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- nuclear foci
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hexim1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- negative regulation of transcription elongation from RNA polymerase II promoter
- activation of innate immune response
- innate immune response
- negative regulation of cyclin-dependent protein kinase activity
- negative regulation of viral transcription
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- snRNA binding
- cyclin-dependent protein kinase inhibitor activity
- protein kinase inhibitor activity