Rtf1 Gene Summary [Mouse]
Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity and single-stranded DNA binding activity. Involved in several processes, including endodermal cell fate commitment; negative regulation of transcription by RNA polymerase II; and stem cell population maintenance. Acts upstream of or within blastocyst growth. Located in nucleolus. Part of Cdc73/Paf1 complex. Is expressed in several structures, including brain and retina nuclear layer. Used to study dilated cardiomyopathy. Orthologous to human RTF1 (RTF1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rtf1 |
| Official Name | RTF1, Paf1/RNA polymerase II complex component [Source:MGI Symbol;Acc:MGI:1309480] |
| Ensembl ID | ENSMUSG00000027304 |
| Bio databases IDs | |
| Aliases | RTF1, Paf1/RNA polymerase II complex component |
| Synonyms | 2900005O08RIK, 6530416A09Rik, cbp82, GTL7, KIAA0252, RTF1 homolog, Paf1/RNA polymerase II complex component, RTF1, Paf1/RNA polymerase II complex component, Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rtf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA binding
- protein binding
- Plus-3 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- asthma
- ulcerative colitis
- COVID-19
- schizophrenia
- allergic rhinitis
regulates
- NFkB (complex)
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- activation in
- maintenance
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rtf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- stem cell maintenance
- endodermal cell fate commitment
- blastocyst growth
- Wnt receptor signaling pathway
- chromatin organization
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- Cdc73/Paf1 complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- single-stranded DNA binding