Nedd4 Gene Summary [Mouse]
Enables several functions, including ionotropic glutamate receptor binding activity; proline-rich region binding activity; and protein phosphorylated amino acid binding activity. Involved in negative regulation of vascular endothelial growth factor receptor signaling pathway and regulation of dendrite morphogenesis. Acts upstream of or within several processes, including circulatory system development; protein monoubiquitination; and regulation of primary metabolic process. Located in cytosol and membrane. Part of ubiquitin ligase complex. Is active in glutamatergic synapse and postsynaptic cytosol. Is expressed in several structures, including alimentary system; eye; genitourinary system; limb; and nervous system. Orthologous to human NEDD4 (NEDD4 E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nedd4 |
| Official Name | neural precursor cell expressed, developmentally down-regulated 4 [Source:MGI Symbol;Acc:MGI:97297] |
| Ensembl ID | ENSMUSG00000032216 |
| Bio databases IDs | |
| Aliases | neural precursor cell expressed, developmentally down-regulated 4 |
| Synonyms | E430025J12Rik, EG639396, Gm7265, KIAA0093, NEDD4-1, NEDD4.1, NEDD4A, NEDD4 E3 ubiquitin protein ligase, neural precursor cell expressed, developmentally down-regulated 4, RPF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nedd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid binding domain
- G-protein-coupled receptor binding
- enzyme
- phosphoprotein amino acid binding
- Domain with 2 conserved Trp (W) residues
- WW
- ion channel binding
- C2 domain
- catalytic domain
- ubiquitin protein ligase activity
- WW class I binding domain
- Domain Homologous to E6-AP Carboxyl Terminus with
- channel inhibitor
- enzyme binding
- protein domain specific binding
- ubiquitin binding
- protein binding
- ionotropic glutamate receptor binding
- potassium channel inhibitor
- WW domain
- sodium channel inhibitor
- acid-D-amino acid ligase
- HECTc
- ubiquitin ligase-like domain
- ubiquitin-protein transferase activity
- Protein kinase C conserved region 2 (CalB)
Pathways
Biological processes and signaling networks where the Nedd4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- endometrial cancer
- epithelial cancer
- rheumatoid arthritis
- tuberculosis
- Dupuytren contracture
- bleeding
- hepatocellular carcinoma
- keloid
- open-angle glaucoma
role in cell
- expression in
- accumulation in
- phosphorylation in
- binding in
- growth
- apoptosis
- degradation in
- proliferation
- transactivation in
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- apicolateral membrane
- glutaminergic synapse
- perinuclear region
- cellular membrane
- cell cortex
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- trans Golgi network
- nucleoplasm
- microvilli
- chromatin
- clathrin-coated vesicles
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nedd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- non-lytic virus budding
- protein targeting to lysosome
- regulation of dendrite morphogenesis
- negative regulation of transcription from RNA polymerase II promoter
- neuromuscular junction development
- receptor catabolic process
- negative regulation of vascular endothelial growth factor receptor signaling pathway
- cellular response to UV
- regulation of ion transmembrane transport
- negative regulation of sodium ion transmembrane transporter activity
- glucocorticoid receptor signaling pathway
- regulation of synapse organization
- neuron projection development
- lysosomal transport
- positive regulation of protein catabolic process
- positive regulation of nucleocytoplasmic transport
- response to DNA damage stimulus
- ubiquitin-dependent protein catabolic process
- regulation of membrane potential
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- innate immune response
- response to calcium ion
- development involved in symbiotic interaction
- progesterone receptor signaling pathway
- regulation of macroautophagy
- protein K63-linked ubiquitination
- negative regulation of sodium ion transport
- receptor internalization
- positive regulation of protein kinase B signaling cascade
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- apicolateral plasma membrane
- Golgi apparatus
- chromatin
- plasma membrane
- nucleus
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- ubiquitin ligase complex
- cytoplasm
- cell cortex
- dendritic spine
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- RNA polymerase binding
- proline-rich region binding
- protein domain specific binding
- protein binding
- ubiquitin binding
- phosphothreonine binding
- phosphoserine binding
- sodium channel inhibitor activity
- beta-2 adrenergic receptor binding
- enzyme binding