Bub1 Gene Summary [Mouse]
Predicted to enable histone H2A kinase activity and protein serine/threonine kinase activity. Acts upstream of or within chromosome segregation and positive regulation of intrinsic apoptotic signaling pathway. Located in kinetochore. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer and primary autosomal recessive microcephaly 30. Orthologous to human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bub1 |
| Official Name | BUB1, mitotic checkpoint serine/threonine kinase [Source:MGI Symbol;Acc:MGI:1100510] |
| Ensembl ID | ENSMUSG00000027379 |
| Bio databases IDs | |
| Aliases | BUB1, mitotic checkpoint serine/threonine kinase |
| Synonyms | BUB1A, BUB1L, BUB1 mitotic checkpoint serine/threonine kinase, BUB1, mitotic checkpoint serine/threonine kinase, D2Xrf87, hBUB1, MCPH30 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bub1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- protein kinase
- Mad3/BUB1 homology region 1
- Protein Kinases, catalytic domain
- protein binding
- enzyme
- tetratricopeptide repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- Alzheimer disease
- organismal death
- prostate cancer
- non-small cell lung cancer
role in cell
- apoptosis
- cell death
- proliferation
- growth
- number
- mitosis
- missegregation
- cell cycle progression
- abnormal morphology
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- cytosol
- nucleoplasm
- mitotic spindle
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bub1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- regulation of chromosome segregation
- cell division
- chromatin remodeling
- regulation of sister chromatid cohesion
- apoptotic process
- chromosome segregation
- positive regulation of maintenance of mitotic sister chromatid cohesion, centromeric
- meiotic sister chromatid cohesion, centromeric
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- membrane
- cytosol
- kinetochore
- condensed chromosome outer kinetochore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity