Knstrn Gene Summary [Mouse]
Predicted to enable microtubule plus-end binding activity and protein homodimerization activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; mitotic sister chromatid segregation; and regulation of attachment of spindle microtubules to kinetochore. Predicted to be located in microtubule organizing center; plasma membrane; and ruffle. Predicted to be active in kinetochore and microtubule cytoskeleton. Is expressed in cerebral cortex ventricular layer. Human ortholog(s) of this gene implicated in actinic keratosis and skin squamous cell carcinoma. Orthologous to human KNSTRN (kinetochore localized astrin (SPAG5) binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Knstrn |
| Official Name | kinetochore-localized astrin/SPAG5 binding [Source:MGI Symbol;Acc:MGI:1289298] |
| Ensembl ID | ENSMUSG00000027331 |
| Bio databases IDs | |
| Aliases | kinetochore-localized astrin/SPAG5 binding |
| Synonyms | 1700025D04Rik, C15orf23, D2Ertd750e, FLJ14502, HSD11, kinetochore-localized astrin/SPAG5 binding, kinetochore localized astrin (SPAG5) binding protein, kinetochore-localized astrin/SPAG5 binding protein, RCHTS, ROCHIS, SKAP, TRAF4AF1, TRAF4 ASSOCIATED FACTOR 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Knstrn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein homodimerization
- microtubule plus-end binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- bladder cancer
- oligozoospermia
- skin squamous cell carcinoma
- squamous cell skin cancer
- Roifman-Chitayat syndrome
- colon cancer
- metastasis
- actinic keratosis
regulates
- AKT
- phosphatidylinositol triphosphate
role in cell
- migration
- apoptosis
- proliferation
- phosphorylation in
- segregation
- invasion by
- organization
- gemcitabine sensitivity
- abnormal morphology
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ruffle
- Plasma Membrane
- centrosome
- microtubules
- microtubule organizing centers
- mitotic spindle
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Knstrn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- spindle organization
- cellular response to epidermal growth factor stimulus
- mitotic sister chromatid segregation
- chromosome segregation
- microtubule cytoskeleton organization
- regulation of attachment of spindle microtubules to kinetochore
- cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitotic spindle
- microtubule organizing center
- microtubule plus end
- cytoplasm
- centriolar satellite
- spindle pole
- ruffle
- kinetochore
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- microtubule plus-end binding