Otud4 Gene Summary [Mouse]
Enables K63-linked deubiquitinase activity. Involved in negative regulation of interleukin-1-mediated signaling pathway; negative regulation of toll-like receptor signaling pathway; and protein K63-linked deubiquitination. Predicted to be located in cytosol. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Orthologous to human OTUD4 (OTU deubiquitinase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Otud4 |
| Official Name | OTU domain containing 4 [Source:MGI Symbol;Acc:MGI:1098801] |
| Ensembl ID | ENSMUSG00000036990 |
| Bio databases IDs | |
| Aliases | OTU domain containing 4 |
| Synonyms | 4930431L18Rik, D8Ertd69e, DKFZp434I0721, DUBA6, HIN1, HSHIN1, mKIAA1046, OTU deubiquitinase 4, OTU domain containing 4, RGD1305606 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Otud4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- ubiquitin-specific protease
- protein binding
- Tudor domain superfamily
- OTU (ovarian tumor) domain family
- ubiquitin-like-specific protease
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Otud4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- DNA dealkylation involved in DNA repair
- negative regulation of toll-like receptor signaling pathway
- innate immune response
- proteolysis
- negative regulation of interleukin-1-mediated signaling pathway
- protein K63-linked deubiquitination
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- RNA binding
- binding, bridging