Mapre1 Gene Summary [Mouse]
Enables microtubule plus-end binding activity. Involved in microtubule bundle formation and microtubule polymerization. Acts upstream of or within non-motile cilium assembly; protein localization to centrosome; and protein localization to microtubule. Located in Golgi apparatus; cell projection membrane; and microtubule cytoskeleton. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human MAPRE1 (microtubule associated protein RP/EB family member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mapre1 |
| Official Name | microtubule-associated protein, RP/EB family, member 1 [Source:MGI Symbol;Acc:MGI:891995] |
| Ensembl ID | ENSMUSG00000027479 |
| Bio databases IDs | |
| Aliases | microtubule-associated protein, RP/EB family, member 1 |
| Synonyms | 5530600P05RIK, BIM1p, D2Ertd459e, EB1, microtubule associated protein RP/EB family member 1, microtubule-associated protein, RP/EB family, member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mapre1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calponin homology domain
- protein kinase binding
- calponin homology (CH) domain superfamily
- cysteine-histidine rich domain
- APC binding domain
- coiled-coil domain
- microtubule plus-end binding
- leucine zipper domain
- protein binding
- identical protein binding
- acidic domain
- EB1-like C-terminal motif
Pathways
Biological processes and signaling networks where the Mapre1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- attention deficit hyperactivity disorder
- epithelial cancer
- breast carcinoma
- hepatocellular carcinoma
- liver cancer
- prostate cancer
- rheumatoid arthritis
- colon cancer
- prostatic carcinoma
- polycystic ovary syndrome
role in cell
- growth
- migration
- polymerization in
- truncation
- formation
- instability
- binding
- tilting
- bundling
- dissociation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- spindle apparatus
- dendritic growth cone
- focal adhesions
- filamentous network
- Nucleus
- Plasma Membrane
- basal bodies
- centrosome
- Golgi Apparatus
- centriole
- microtubules
- microtubule tips
- cytosol
- uropod
- spindle pole
- spindle fibers
- growth cone
- plus end of microtubule
- cellular protrusions
- pseudopodia
- mitotic spindle
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mapre1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization to microtubule
- protein localization
- microtubule polymerization
- cell division
- spindle assembly
- establishment of mitotic spindle orientation
- microtubule bundle formation
- regulation of microtubule polymerization or depolymerization
- positive regulation of microtubule polymerization
- protein localization to centrosome
- cell migration
- attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
- negative regulation of microtubule polymerization
Cellular Component
Where in the cell the gene product is active
- microtubule plus end
- cilium basal body
- Golgi apparatus
- cytoplasmic microtubule
- microtubule
- centrosome
- spindle midzone
- microtubule organizing center
- focal adhesion
- spindle
- cytosol
- cortical microtubule cytoskeleton
- cell projection membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- identical protein binding
- RNA binding
- protein binding
- cadherin binding
- microtubule plus-end binding