Fbln7 Gene Summary [Mouse]
Enables heparan sulfate proteoglycan binding activity and heparin binding activity. Predicted to be involved in cell adhesion. Located in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; reproductive system; respiratory system; and skeleton. Orthologous to human FBLN7 (fibulin 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbln7 |
| Official Name | fibulin 7 [Source:MGI Symbol;Acc:MGI:1917620] |
| Ensembl ID | ENSMUSG00000027386 |
| Bio databases IDs | |
| Aliases | fibulin 7 |
| Synonyms | 1600015H20Rik, AI464334, fibulin 7, RGD1310131, TM14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbln7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCP
- Complement Clr-like EGF-like
- binding protein
- Human growth factor-like EGF
- protein binding
- Sushi repeat (SCR repeat)
- heparin binding
- Coagulation Factor Xa inhibitory site
- SUSHI repeat
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertrophic cardiomyopathy
- diabetic nephropathy
- dilated cardiomyopathy
- cardiac fibrosis
- metabolic syndrome X
- systemic juvenile idiopathic arthritis
- nephrocalcinosis
- tubulo-interstitial fibrosis
role in cell
- phosphorylation in
- function
- autophosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- apical cell surfaces
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbln7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- focal adhesion
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- heparan sulfate proteoglycan binding
- heparin binding