Ptk2 Gene Summary [Mouse]
Enables non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including positive regulation of ubiquitin-dependent protein catabolic process; protein phosphorylation; and regulation of modification of postsynaptic actin cytoskeleton. Acts upstream of or within several processes, including blood vessel morphogenesis; generation of neurons; and negative regulation of nervous system development. Located in several cellular components, including apical plasma membrane; focal adhesion; and lamellipodium. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and vault of skull. Human ortholog(s) of this gene implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Orthologous to human PTK2 (protein tyrosine kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptk2 |
| Official Name | PTK2 protein tyrosine kinase 2 [Source:MGI Symbol;Acc:MGI:95481] |
| Ensembl ID | ENSMUSG00000022607 |
| Bio databases IDs | |
| Aliases | PTK2 protein tyrosine kinase 2 |
| Synonyms | FADK, FADK 1, FAK, FAK1, FAK related non-kinase, p125FAK, pp125FAK, PPP1R71, protein tyrosine kinase 2, PTK2 protein tyrosine kinase 2, TYROSINE KINASE 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PI3K binding domain
- Src binding domain
- FAK kinase domain
- ATP-binding domain
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- proline rich domain
- Sh3 domain binding motif
- FERM domain
- proline and tyrosine-rich region
- Focal adhesion targeting region
- actin binding
- FERM domain B-lobe
- Tyrosine kinase, catalytic domain
- phosphatase binding
- FERM central domain
- Band 4.1 homologues
- Protein kinase (unclassified specificity)
- protein kinase binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- SH2-domain binding
- protein phosphatase binding
- paxillin-binding domain
- non-membrane spanning protein tyrosine kinase
- JUN kinase binding
- autophosphorylation site
- protein binding
- Pleckstrin homology-like domain
- Src-homology 2 binding domain
- polyproline motif
- FERM N-terminal domain
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- phosphoinositide 3-kinase binding
- binding protein
- Protein Kinases, catalytic domain
- integrin binding
- PXXP motif
Pathways
Biological processes and signaling networks where the Ptk2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- Chemokine Signaling
- CXCR4 Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Ephrin A Signaling
- Ephrin Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioma Invasiveness Signaling
- Gα12/13 Signaling
- HGF Signaling
- IGF-1 Signaling
- IL-7 Signaling Pathway
- PAK Signaling
- Paxillin Signaling
- Regulation of Cellular Mechanics by Calpain Protease
- RHOA Signaling
- Semaphorin Signaling in Neurons
- Signaling by Rho Family GTPases
- Small Cell Lung Cancer Signaling
- Thrombin Signaling
- VEGF Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastatic non-small cell lung cancer
- advanced rectal cancer
- metastatic rectal cancer
- recurrent pancreatic adenocarcinoma
- advanced non-small cell lung cancer
- advanced non-small cell lung adenocarcinoma
- adenocarcinoma of the small bowel
- advanced large cell lung carcinoma
- biliary tract cancer
role in cell
- growth
- proliferation
- cell death
- G1 phase
- production in
- expression in
- inhibition in
- length
- activation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- soluble fraction
- postsynaptic density (PSD) fractions
- insoluble fractions
- synaptosomal membrane fractions
- apical ectoplasmic specialization
- glutaminergic synapse
- filopodia-like projection
- intracellular membrane-bounded organelle
- cytoskeleton
- cilia
- cell periphery
- intracellular space
- perinuclear region
- postsynaptic region
- cellular membrane
- focal complexes
- focal adhesions
- membrane skeleton
- Nucleus
- Plasma Membrane
- basal bodies
- endosomes
- actin filaments
- intercellular junctions
- cell-cell contacts
- cytosol
- apical cytoplasm
- basolateral cell surfaces
- apical membrane
- caveolae
- basolateral membrane
- basal membrane
- nuclear bodies
- dendritic spines
- neurites
- synaptosomes
- intercalated disks
- sarcolemma
- actin stress fibers
- cellular protrusions
- filopodia
- cell membrane leading edge
- perikaryon
- plasma
- lamellipodia
- cytoskeletal fraction
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- signal complex assembly
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- peptidyl-tyrosine phosphorylation
- epidermal growth factor receptor signaling pathway
- negative regulation of cell-cell adhesion
- positive regulation of cell proliferation
- transforming growth factor beta receptor signaling pathway
- protein autophosphorylation
- axon guidance
- Fc-gamma receptor signaling pathway involved in phagocytosis
- placenta development
- protein phosphorylation
- regulation of osteoblast differentiation
- positive regulation of epithelial to mesenchymal transition
- heart morphogenesis
- integrin-mediated signaling pathway
- negative regulation of anoikis
- angiogenesis
- positive regulation of macrophage chemotaxis
- regulation of epithelial cell migration
- positive regulation of epithelial cell migration
- detection of muscle stretch
- netrin-activated signaling pathway
- cell migration
- growth hormone receptor signaling pathway
- regulation of endothelial cell migration
- positive regulation of wound healing
- regulation of substrate adhesion-dependent cell spreading
- regulation of cell proliferation
- cell motility
- regulation of cell adhesion mediated by integrin
- vascular endothelial growth factor receptor signaling pathway
- regulation of focal adhesion assembly
- positive regulation of protein kinase activity
- regulation of protein phosphorylation
- regulation of cytoskeleton organization
- negative regulation of apoptotic process
- positive regulation of protein phosphorylation
- ephrin receptor signaling pathway
- regulation of GTPase activity
- establishment of cell polarity
- regulation of cell adhesion
- positive regulation of protein kinase B signaling cascade
- positive regulation of fibroblast migration
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- plasma membrane
- nucleus
- centrosome
- cytoskeleton
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- cell cortex
- intracellular membrane-bounded organelle
- stress fiber
- dendritic spine
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- protein tyrosine kinase activity
- protein binding
- protein phosphatase binding
- non-membrane spanning protein tyrosine kinase activity
- actin binding
- protein tyrosine phosphatase activity
- JUN kinase binding
- integrin binding
- SH2 domain binding