Clns1a Gene Summary [Mouse]
Involved in negative regulation of cell volume. Predicted to be located in nucleoplasm. Predicted to be part of methylosome; pICln-Sm protein complex; and spliceosomal complex. Predicted to be active in cytosol. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human CLNS1A (chloride nucleotide-sensitive channel 1A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clns1a |
| Official Name | chloride channel, nucleotide-sensitive, 1A [Source:MGI Symbol;Acc:MGI:109638] |
| Ensembl ID | ENSMUSG00000025439 |
| Bio databases IDs | |
| Aliases | chloride channel, nucleotide-sensitive, 1A |
| Synonyms | 2610036D06Rik, 2610100O04Rik, chloride channel, nucleotide-sensitive, 1A, chloride nucleotide-sensitive channel 1A, CLCI, CLCNI, CLNS1B, ICLN, PICLN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Clns1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- lipid binding
- binding protein
- intracellular calcium activated chloride channel
- protein binding
- acidic domain
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cilia
- cellular membrane
- Nucleus
- cytosol
- apical membrane
- basolateral membrane
- nucleoplasm
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Clns1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear mRNA cis splicing, via spliceosome
- positive regulation of nuclear mRNA splicing, via spliceosome
- chloride transport
- cell volume homeostasis
- spliceosomal snRNP assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- pICln-Sm protein complex
- methylosome
- cytosol
- spliceosomal complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding