Lpin3 Gene Summary [Mouse]
Enables phosphatidate phosphatase activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; positive regulation of transcription by RNA polymerase II; and triglyceride biosynthetic process. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; genitourinary system; gut; skin; and trachea. Orthologous to human LPIN3 (lipin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lpin3 |
| Official Name | lipin 3 [Source:MGI Symbol;Acc:MGI:1891342] |
| Ensembl ID | ENSMUSG00000027412 |
| Bio databases IDs | |
| Aliases | lipin 3 |
| Synonyms | 9130206L11Rik, dJ620E11.2, LIPIN 3, LIPN3L, mKIAA4023, SMP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lpin3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lipin/Ned1/Smp2 multi-domain protein middle domain
- phosphatidate phosphatase
- phosphatase
- LNS2 (Lipin/Ned1/Smp2)
- lipin, N-terminal conserved region
- Haloacid Dehalogenase-like Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lpin3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- fatty acid catabolic process
- triglyceride biosynthetic process
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
Molecular Function
What the gene product does at the molecular level
- phosphatidate phosphatase activity
- transcription coactivator activity