Ptpn13 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol 3-kinase regulatory subunit binding activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including negative regulation of excitatory synapse assembly; peptidyl-tyrosine dephosphorylation; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in cytoplasm; midbody; and nucleus. Is expressed in several structures, including brain; epithelium; genitourinary system; gut; and humerus cartilage condensation. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); and colorectal cancer (multiple). Orthologous to human PTPN13 (protein tyrosine phosphatase non-receptor type 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ptpn13 |
| Official Name | protein tyrosine phosphatase, non-receptor type 13 [Source:MGI Symbol;Acc:MGI:103293] |
| Ensembl ID | ENSMUSG00000034573 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 13 |
| Synonyms | FAP-1, Fas-associated phosphatase-1, hPTP1E, LOC100910240, LOC498331, PNP1, protein TYROSINE PHOSPHATASE1E, protein tyrosine phosphatase non-receptor type 13, protein tyrosine phosphatase, non-receptor type 13, ptp, PTP1E, PTP-BAS, PTP-BAS5E, PTP-BL, PTPL1, PTPLE, Ptpri, RIP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpn13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-tyrosine-phoshatase
- Protein tyrosine phosphatase, catalytic domain
- PTP_DSP_cys
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- FERM domain
- Protein-tyrosine phosphatase
- phosphatase
- FERM domain B-lobe
- FERM central domain
- Band 4.1 homologues
- Domain present in PSD-95, Dlg, and ZO-1/2
- canonical PDZ domain
- protein binding
- Pleckstrin homology-like domain
- PDZ domain
- phosphatase domain
- PTPase domain
- FERM N-terminal domain
- phosphoinositide 3-kinase binding
- Protein Kinases, catalytic domain
- Unstructured linker region on PTN13 protein between PDZ
- Ubl1_cv_Nsp3_N-like
- cpPDZ_Deg_HtrA-like
- FERM C-terminal PH-like domain
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the Ptpn13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- pancreatic adenocarcinoma
- pancreatic epithelial cancer
- organismal death
- tinnitus
- Rett syndrome
- latent tuberculosis
- infection by bacteria
role in cell
- proliferation
- expression in
- growth
- survival
- binding in
- signaling in
- apoptosis
- number
- assembly
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- insoluble fractions
- detergent resistant lipid raft fraction
- fibrillar center
- Nucleus
- Plasma Membrane
- midbody
- cytosol
- apical cell surfaces
- nucleoplasm
- membrane rafts
- perikaryon
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpn13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein kinase B signaling cascade
- negative regulation of protein phosphorylation
- cellular response to toxin
- protein dephosphorylation
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- extracellular vesicular exosome
- cytoplasm
- cell body
- cytosol
- plasma membrane
- fibrillar center
- lamellipodium
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tyrosine phosphatase activity