Cop1 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasome-mediated ubiquitin-dependent protein catabolic process; and response to ionizing radiation. Predicted to be located in Golgi membrane. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex. Is expressed in several structures, including central nervous system; genitourinary system; limb; and liver. Orthologous to human COP1 (COP1 E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Cop1 |
| Official Name | COP1, E3 ubiquitin ligase [Source:MGI Symbol;Acc:MGI:1347046] |
| Ensembl ID | ENSMUSG00000040782 |
| Bio databases IDs | |
| Aliases | COP1, E3 ubiquitin ligase |
| Synonyms | AI316802, C80879, CFAP78, COP, COP1 E3 ubiquitin ligase, COP1, E3 ubiquitin ligase, FAP78, LOC120096294, RFWD2, RGD1304773, RNF200 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cop1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- WD domain, G-beta repeat
- central domain
- BRcat_Rcat_RBR
- coiled-coil domain
- WD40
- enzyme
- Ring finger domain
- protein binding
- WD40 repeats
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the Cop1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- irritable bowel syndrome
- Alzheimer disease
- major depression
- gastric cancer
- neonatal late-onset sepsis
role in cell
- signaling in
- ubiquitination in
- activation in
- apoptosis
- proliferation
- migration
- expression in
- cell death
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- Golgi membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cop1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nuclear speck
- Cul4A-RING ubiquitin ligase complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding