Gss Gene Summary [Mouse]
Enables glutathione synthase activity. Acts upstream of or within response to cadmium ion. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; integumental system; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; congenital nonspherocytic hemolytic anemia 6; glutathione synthetase deficiency; and glutatione synthetase deficiency with 5-oxoprolinuria. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gss |
| Official Name | glutathione synthetase [Source:MGI Symbol;Acc:MGI:95852] |
| Ensembl ID | ENSMUSG00000027610 |
| Bio databases IDs | |
| Aliases | glutathione synthetase |
| Synonyms | CNSHA6, Glutathione synthase, Glutathione synthetase, GS-A/GS-B, GSH-S, HEL-S-64p, HEL-S-88n |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gss often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- Eukaryotic glutathione synthase
- glutathione synthase
- ATP binding
- enzyme
- protein binding
- magnesium ion binding
- identical protein binding
- binding protein
- glycine binding
- protein homodimerization
- eu-GS
- Eukaryotic glutathione synthase, ATP binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- acute renal failure
- chronic bronchitis
- schizophrenia
- acute rhinosinusitis
- the common cold
- mucositis
- thrombocytopenia
- hypertension
- cardiovascular disorder
regulates
- glutathione
- luciferase reporter gene
- amino acids
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gss gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- glutathione biosynthetic process
- nervous system development
- cellular amino acid metabolic process
- response to cadmium ion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- identical protein binding
- protein binding
- protein homodimerization activity
- glutathione binding
- glutathione synthase activity