GSS Gene Summary [Human]
Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GSS |
| Official Name | glutathione synthetase [Source:HGNC Symbol;Acc:HGNC:4624] |
| Ensembl ID | ENSG00000100983 |
| Bio databases IDs | |
| Aliases | glutathione synthetase |
| Synonyms | CNSHA6, Glutathione synthase, Glutathione synthetase, GS-A/GS-B, GSH-S, HEL-S-64p, HEL-S-88n |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GSS often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- Eukaryotic glutathione synthase
- glutathione synthase
- ATP binding
- enzyme
- protein binding
- magnesium ion binding
- identical protein binding
- binding protein
- glycine binding
- protein homodimerization
- eu-GS
- Eukaryotic glutathione synthase, ATP binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- acute renal failure
- chronic bronchitis
- schizophrenia
- acute rhinosinusitis
- the common cold
- mucositis
- thrombocytopenia
- hypertension
- cardiovascular disorder
regulates
- glutathione
- luciferase reporter gene
- amino acids
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GSS gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- glutathione biosynthetic process
- nervous system development
- cellular amino acid metabolic process
- response to cadmium ion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- identical protein binding
- protein binding
- protein homodimerization activity
- glutathione binding
- glutathione synthase activity