Mus81 Gene Summary [Mouse]
Predicted to enable 3'-flap endonuclease activity. Predicted to contribute to crossover junction DNA endonuclease activity. Predicted to be involved in DNA metabolic process; mitotic intra-S DNA damage checkpoint signaling; and osteoblast proliferation. Predicted to act upstream of or within DNA catabolic process and response to intra-S DNA damage checkpoint signaling. Predicted to be located in nuclear replication fork. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus and replication fork. Used to study Marfan syndrome; arterial tortuosity syndrome; and pulmonary emphysema. Orthologous to human MUS81 (MUS81 structure-specific endonuclease subunit). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Mus81 |
| Official Name | MUS81 structure-specific endonuclease subunit [Source:MGI Symbol;Acc:MGI:1918961] |
| Ensembl ID | ENSMUSG00000024906 |
| Bio databases IDs | |
| Aliases | MUS81 structure-specific endonuclease subunit |
| Synonyms | 1200008A18Rik, AW045863, MUS81 structure-specific endonuclease subunit, SLX3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mus81 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endonuclease
- ERCC4 domain
- enzyme
- protein binding
- PDDEXK family nucleases
- 3' flap endonuclease
- nuclease domain of XPF/MUS81 family proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- benign neoplasia
- lymphoid cancer
- lymphatic neoplasia
- lymphomagenesis
- cancer
- hematologic cancer
- hematological neoplasia
- neoplasia
- aneurysm
role in cell
- cell death
- expression in
- phosphorylation in
- formation in
- production in
- morphology
- formation
- survival
- activation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mus81 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA catabolic process
- double-strand break repair via break-induced replication
- osteoblast proliferation
- resolution of meiotic recombination intermediates
- replication fork processing
- intra-S DNA damage checkpoint
- response to intra-S DNA damage checkpoint signal
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- replication fork
- nucleus
- Holliday junction resolvase complex
- nuclear replication fork
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- 3'-flap endonuclease activity
- metal ion binding
- endonuclease activity
- crossover junction endodeoxyribonuclease activity