Acp6 Gene Summary [Mouse]
Predicted to enable lysophosphatidic acid phosphatase activity. Acts upstream of or within hematopoietic progenitor cell differentiation. Located in mitochondrion. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human ACP6 (acid phosphatase 6, lysophosphatidic). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acp6 |
| Official Name | acid phosphatase 6, lysophosphatidic [Source:MGI Symbol;Acc:MGI:1931010] |
| Ensembl ID | ENSMUSG00000028093 |
| Bio databases IDs | |
| Aliases | acid phosphatase 6, lysophosphatidic |
| Synonyms | 5730559A09Rik, acid phosphatase 6, lysophosphatidic, ACPL1, LPAP, mPACPL1, PACPL1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acid phosphatase
- phosphatase
- Histidine phosphatase superfamily (branch 2)
- Histidine phosphatase domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- congenital hypothyroidism
- cortical visual impairment and intellectual disability
- intellectual disability and developmental delay
- chronic lymphocytic leukemia
regulates
- phospholipid
- cardiolipin
- lysobisphosphatidic acid
- phosphatidylglycerol
- phosphatidic acid
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dephosphorylation
- phospholipid metabolic process
- lysobisphosphatidic acid metabolic process
- hemopoietic progenitor cell differentiation
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- lysophosphatidic acid phosphatase activity
- acid phosphatase activity