Cryz Gene Summary [Mouse]
Predicted to enable several functions, including NADPH binding activity; NADPH:quinone reductase activity; and mRNA 3'-UTR binding activity. Predicted to be involved in protein homotetramerization and xenobiotic catabolic process. Predicted to be active in cytosol. Is expressed in cerebral cortex ventricular layer; choroid plexus; and cortical plate. Orthologous to human CRYZ (crystallin zeta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cryz |
| Official Name | crystallin, zeta [Source:MGI Symbol;Acc:MGI:88527] |
| Ensembl ID | ENSMUSG00000028199 |
| Bio databases IDs | |
| Aliases | crystallin, zeta |
| Synonyms | Crystallin zeta, crystallin, zeta, Crystallin ζ, crystallin, ζ, Loc362061, Qr, QUINONE REDUCTASE, Sez9, ζ Crystallin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cryz often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADPH binding
- putative NAD(P)H quinone oxidoreductase, PIG3 family
- mRNA 3' UTR binding
- NADP binding
- N-terminal domain of oxidoreductase
- MDR
- Zinc-binding dehydrogenase
- Alcohol dehydrogenase GroES-like domain
- enzyme
- NADPH:quinone reductase
- identical protein binding
- Enoylreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic colorectal cancer
- lung cancer
- systemic sclerosis
- hyperplasia
regulates
- genomic DNA
- xenobiotic
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cryz gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein homotetramerization
- xenobiotic catabolic process
- visual perception
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- NADPH binding
- NADPH:quinone reductase activity
- mRNA 3'-UTR binding
- NADH binding