Rexo4 Gene Summary [Mouse]
Predicted to enable DNA binding activity and nuclease activity. Predicted to be involved in DNA catabolic process; DNA repair; and RNA processing. Predicted to be located in nuclear speck and nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; connective tissue; and genitourinary system. Orthologous to human REXO4 (REX4 homolog, 3'-5' exonuclease). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rexo4 |
| Official Name | REX4, 3'-5' exonuclease [Source:MGI Symbol;Acc:MGI:2684957] |
| Ensembl ID | ENSMUSG00000052406 |
| Bio databases IDs | |
| Aliases | REX4, 3'-5' exonuclease |
| Synonyms | Gm111, PMC2, REX4, REX4, 3'-5' exonuclease, REX4 homolog, 3'-5' exonuclease, XPMC2, XPMC2H |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rexo4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endonuclease
- 3'-5' exonuclease
- transcription regulator
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- single-stranded DNA binding
- double-stranded DNA binding
- exonuclease
- EXOIII
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rexo4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- DNA catabolic process
- regulation of transcription, DNA-dependent
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 3'-5' exonuclease activity
- protein binding
- RNA binding
- exonuclease activity
- endonuclease activity
- double-stranded DNA binding
- single-stranded DNA binding