Pip4p2 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity. Involved in negative regulation of phagocytosis and phosphatidylinositol dephosphorylation. Located in late endosome membrane; phagocytic vesicle membrane; and plasma membrane. Orthologous to human PIP4P2 (phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pip4p2 |
| Official Name | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 [Source:MGI Symbol;Acc:MGI:1919769] |
| Ensembl ID | ENSMUSG00000028221 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 |
| Synonyms | 2610319K07RIK, phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2, PTDINS-4,5-P2 4-PTASE II, PTDINS-4,5-P2 4-PTASE type II, RGD1306225, TMEM55A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pip4p2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transmembrane protein 55A
- phosphatase
- protein binding
- phosphatidylinositol-4,5-bisphosphate 4-phosphatase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- lysosome membrane
- endosomal membrane
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pip4p2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylinositol dephosphorylation
- negative regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- phagocytic vesicle membrane
- plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity