Slc39a5 Gene Summary [Mouse]
Enables zinc ion transmembrane transporter activity. Involved in zinc ion transmembrane transport. Acts upstream of or within cellular response to zinc ion starvation and positive regulation of mRNA splicing, via spliceosome. Located in basolateral plasma membrane. Is expressed in several structures, including branchial arch; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in myopia. Orthologous to human SLC39A5 (solute carrier family 39 member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc39a5 |
| Official Name | solute carrier family 39 (metal ion transporter), member 5 [Source:MGI Symbol;Acc:MGI:1919336] |
| Ensembl ID | ENSMUSG00000039878 |
| Bio databases IDs | |
| Aliases | solute carrier family 39 (metal ion transporter), member 5 |
| Synonyms | 1810013D05RIK, 2010205A06Rik, LZT-Hs7, MYP24, solute carrier family 39 member 5, solute carrier family 39 (metal ion transporter), member 5, ZIP5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc39a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ZIP Zinc transporter
- zinc ion transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- hepatocellular carcinoma
- liver cancer
- autosomal dominant myopia type 24
- pancreatitis
- colon cancer
role in cell
- apoptosis
- proliferation
- quantity
- expression in
- invasion by
- migration by
- Gap 0-Gap 1 phase
- atrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- vesicles
- basolateral cell surfaces
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc39a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- eye development
- positive regulation of nuclear mRNA splicing, via spliceosome
- zinc ion transport
- BMP signaling pathway
- neural precursor cell proliferation
- zinc ion import
- cellular response to zinc ion starvation
- zinc ion transmembrane transport
- bicarbonate transport
- cellular cation homeostasis
- G1 to G0 transition involved in cell differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion transmembrane transporter activity