Rpl13a Gene Summary [Mouse]
Enables mRNA binding activity. A structural constituent of ribosome. Involved in cellular response to type II interferon and negative regulation of translation. Acts upstream of or within several processes, including lung morphogenesis; macrophage chemotaxis; and response to lipopolysaccharide. Located in cytoplasm. Part of GAIT complex and cytosolic large ribosomal subunit. Is active in synapse. Is expressed in early conceptus. Orthologous to human RPL13A (ribosomal protein L13a). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl13a |
| Official Name | ribosomal protein L13A [Source:MGI Symbol;Acc:MGI:1351455] |
| Ensembl ID | ENSMUSG00000074129 |
| Bio databases IDs | |
| Aliases | ribosomal protein L13A |
| Synonyms | 1810026N22Rik, L13A, Ribol13a, ribosomal protein L13A, TSTA1, Tstap198-7, tum-antigen, uL13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl13a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal protein L13
- Ribosomal_L13
- structural constituent of ribosome
- mRNA binding
Pathways
Biological processes and signaling networks where the Rpl13a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cholangiocarcinoma
- cholangiocarcinoma cancer
- Parkinson disease
- myelodysplastic syndrome
role in cell
- binding in
- cellular infiltration by
- expression in
- cell death
- production in
- replication in
- binding
- phagocytic capacity
- response by
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- ribosome
- Nucleus
- cytosol
- nucleoli
- synapse
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl13a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macrophage chemotaxis
- cytoplasmic translation
- homeostatic process
- response to lipopolysaccharide
- cellular response to interferon-gamma
- negative regulation of translation
- lung morphogenesis
- translation
Cellular Component
Where in the cell the gene product is active
- nucleus
- focal adhesion
- cytosolic ribosome
- cytoplasm
- membrane
- cytosol
- large ribosomal subunit
- cytosolic large ribosomal subunit
- synapse
- nucleolus
- ribosome
Molecular Function
What the gene product does at the molecular level
- RNA binding
- structural constituent of ribosome
- mRNA binding