Fhl5 Gene Summary [Mouse]
Enables transcription coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be active in Z disc and nucleus. Is expressed in central nervous system; genitourinary system; heart; and otocyst. Orthologous to human FHL5 (four and a half LIM domains 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fhl5 |
| Official Name | four and a half LIM domains 5 [Source:MGI Symbol;Acc:MGI:1913192] |
| Ensembl ID | ENSMUSG00000028259 |
| Bio databases IDs | |
| Aliases | four and a half LIM domains 5 |
| Synonyms | 1700027G07Rik, ACT, dJ393D12.2, four and a half LIM domains 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fhl5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- half LIM domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- non-small cell lung cancer
- headache
- asthenozoospermia
- atherosclerosis
- myocardial infarction
- migraine without aura
- lung adenocarcinoma
- lung adenocarcinoma formation
- migraine with aura
role in cell
- formation
- quantity
- abnormal morphology
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fhl5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- Z disc
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- metal ion binding