Gbp3

Predicted to enable GTP binding activity; GTPase activity; and protein homodimerization activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of defense response; and response to bacterium. Acts upstream of or within adhesion of symbiont to host and defense response to other organism. Located in cytoplasmic vesicle; cytosol; and symbiont-containing vacuole membrane. Orthologous to human GBP4 (guanylate binding protein 4) and GBP7 (guanylate binding protein 7). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gbp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.