Klf4 Gene Summary [Mouse]
Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity. Involved in several processes, including canonical Wnt signaling pathway; establishment of skin barrier; and fat cell differentiation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of DNA-templated transcription; and regulation of blastocyst development. Located in cytoplasm; euchromatin; and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; limb; and skin. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human KLF4 (KLF transcription factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klf4 |
| Official Name | Kruppel-like factor 4 (gut) [Source:MGI Symbol;Acc:MGI:1342287] |
| Ensembl ID | ENSMUSG00000003032 |
| Bio databases IDs | |
| Aliases | Kruppel-like factor 4 (gut) |
| Synonyms | EZF, GKLF, KLF transcription factor 4, Kruppel-like transcription factor 4 (gut), Zie |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- acetylation site
- DNA binding domain
- beta-catenin binding
- nucleic acid binding
- protein binding activity, bridging
- KLF1_2_4_N
- transcription factor binding
- histone deacetylase binding
- chromatin binding
- phosphoinositide 3-kinase regulator
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- N-terminal transactivation domain
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Klf4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetes mellitus
- metastasis
- epithelial cancer
- breast cancer
- lymphoma
- lung cancer
- prostate cancer
- lymphomagenesis
- peripheral arterial disease
role in cell
- expression in
- phosphorylation in
- binding in
- quantity
- growth
- apoptosis
- production in
- induction
- recruitment in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- microtubule cytoskeleton
- Cytoplasm
- cell surface
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- post-embryonic hemopoiesis
- negative regulation of angiogenesis
- negative regulation of response to cytokine stimulus
- positive regulation of nitric oxide biosynthetic process
- negative regulation of cell proliferation
- transcription from RNA polymerase II promoter
- regulation of axon regeneration
- fat cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- glandular epithelial cell differentiation
- negative regulation of cell migration involved in sprouting angiogenesis
- establishment of skin barrier
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of protein metabolic process
- defense response to tumor cell
- negative regulation of transcription, DNA-dependent
- regulation of cell differentiation
- positive regulation of transcription, DNA-dependent
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of smooth muscle cell proliferation
- somatic stem cell maintenance
- negative regulation of G1/S transition of mitotic cell cycle
- canonical Wnt receptor signaling pathway
- cellular response to laminar fluid shear stress
- post-embryonic camera-type eye development
- cellular response to hydrogen peroxide
- stem cell maintenance
- cellular response to cycloheximide
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of inflammatory response
- positive regulation of hemoglobin biosynthetic process
- mesodermal cell fate determination
- regulation of transcription from RNA polymerase II promoter
- negative regulation of gene expression
- positive regulation of telomerase activity
- epidermal cell differentiation
- epidermis morphogenesis
- cellular response to retinoic acid
- cellular response to growth factor stimulus
- positive regulation of gene expression
- negative regulation of interleukin-8 production
- negative regulation of heterotypic cell-cell adhesion
- negative regulation of chemokine (C-X-C motif) ligand 2 production
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- euchromatin
- microtubule cytoskeleton
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- chromatin DNA binding
- zinc ion binding
- histone deacetylase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- beta-catenin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- transcription cofactor binding
- sequence-specific DNA binding transcription factor activity
- sequence-specific DNA binding transcription factor recruiting transcription factor activity
- protein binding