Npr2 Gene Summary [Mouse]
Enables guanylate cyclase activity; identical protein binding activity; and natriuretic peptide receptor activity. Involved in several processes, including reproductive structure development; skeletal system development; and vasculature development. Acts upstream of or within bone development; negative regulation of meiotic cell cycle; and negative regulation of oocyte maturation. Is active in several cellular components, including cilium; neuron projection; and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Used to study achondroplasia; acromesomelic dysplasia, Maroteaux type; and bone development disease. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npr2 |
| Official Name | natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372] |
| Ensembl ID | ENSMUSG00000028469 |
| Bio databases IDs | |
| Aliases | natriuretic peptide receptor 2 |
| Synonyms | AMD1, AMDM, Anf receptor 2, ANP-B, ANPRB, cn, ECDM, GC-B, GC-B2, GC-B3, Guanylate cyclase B, GUC2B, GUCY2B, mNPR-B, natriuretic peptide receptor 2, NPR-B, NPRBi, pwe, SNSK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Npr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- natriuretic peptide receptor
- Receptor family ligand binding region
- hormone binding
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- identical protein binding
- polypeptide hormone binding
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Type 1 periplasmic binding fold superfamily
- guanylate cyclase
- Class III nucleotidyl cyclases
- Adenylyl- / guanylyl cyclase, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Npr2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Antiproliferative Role of Somatostatin Receptor 2
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- Corticotropin Releasing Hormone Signaling
- Endothelin-1 Signaling
- Gap Junction Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Phototransduction Pathway
- Relaxin Signaling
- Synaptic Long Term Depression
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- essential hypertension
- disorder of coronary artery
- cardiovascular disorder
- acute renal failure
- heart failure
- cardiac hypertrophy
- heart disease
- renal impairment
- congestive heart failure
phenotypes
- abnormal forelimb morphology
- abnormal gait
- abnormal head morphology
- abnormal head size
- abnormal hindlimb morphology
- abnormal locomotor behavior
- abnormal snout morphology
- abnormal tail length
- abnormal tail morphology
- decreased exploration in new environment
- limb grasping
- tremors
- trunk curl
- abnormal axial skeleton morphology
- abnormal basicranium morphology
- abnormal blood circulation
- abnormal body weight
- abnormal bone trabecula morphology
- abnormal cervical atlas morphology
- abnormal chondrocyte morphology
- abnormal craniofacial morphology
- abnormal cranium morphology
- abnormal digestive system physiology
- abnormal dorsal root ganglion morphology
- abnormal endochondral bone ossification
- abnormal female meiosis
- abnormal intestine physiology
- abnormal long bone epiphyseal plate morphology
- abnormal long bone epiphyseal plate proliferative zone
- abnormal long bone hypertrophic chondrocyte zone
- abnormal mandibular condyloid process morphology
- abnormal nose morphology
- abnormal oogenesis
- abnormal pelvic girdle bone morphology
- abnormal postnatal growth/weight/body size
- abnormal pyloric sphincter morphology
- abnormal sensory neuron innervation pattern
- abnormal skeleton development
- abnormal spinal cord dorsal column morphology
- abnormal trigeminal nerve morphology
- abnormal uterus morphology
- absent corpus luteum
- absent estrous cycle
- brachydactyly
- chondrodystrophy
- cyanosis
- decreased body length
- decreased body size
- decreased body weight
- decreased cranium length
- decreased cranium width
- decreased length of long bones
- decreased litter size
- decreased long bone epiphyseal plate size
- decreased survivor rate
- decreased width of hypertrophic chondrocyte zone
- delayed vaginal opening
- disorganized long bone epiphyseal plate
- disproportionate dwarf
- distended abdomen
- domed cranium
- embryonic lethality incomplete penetrance
- enlarged interparietal bone
- enlarged parietal bone
- female infertility
- impaired gastric peristalsis
- impaired muscle relaxation
- increased diameter of femur
- long incisors
- long lower incisors
- long upper incisors
- malocclusion
- meteorism
- micromelia
- postnatal growth retardation
- postnatal lethality incomplete penetrance
- premature death
- reduced fertility
- reduced male fertility
- round head
- short femur
- short humerus
- short limbs
- short maxilla
- short radius
- short scapula
- short snout
- short tail
- short tibia
- short ulna
- short vertebral column
- small nasal bone
- small ovary
- small spleen
- small supraoccipital bone
- small uterus
- splayed ribs
- thick tail
- thin endometrium
- thin myometrium
- thin uterine horn
role in cell
- apoptosis
- proliferation
- expression in
- differentiation
- phosphorylation in
- accumulation in
- development
- maturation
- organization
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- Cytoplasm
- cilia
- cellular membrane
- Nucleus
- neurites
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Npr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- axonogenesis involved in innervation
- cGMP biosynthetic process
- negative regulation of oocyte maturation
- vacuole organization
- epidermal growth factor receptor signaling pathway
- gastric emptying
- chondrocyte differentiation
- vasculogenesis
- activation of meiosis involved in egg activation
- execution phase of apoptosis
- sensory perception of sound
- white fat cell differentiation
- MAPK cascade
- startle response
- lymph vessel development
- cumulus cell differentiation
- response to fibroblast growth factor stimulus
- female genitalia development
- neuron apoptotic process
- regulation of action potential in neuron
- negative regulation of meiotic cell cycle
- genitalia morphogenesis
- vestibulocochlear nerve maturation
- vascular wound healing
- spermatogenesis
- receptor guanylyl cyclase signaling pathway
- synaptic transmission
- smooth muscle tissue development
- collateral sprouting
- digestive tract morphogenesis
- regulation of blood pressure
- cellular response to granulocyte macrophage colony-stimulating factor stimulus
- blood vessel remodeling
- cellular response to cGMP
- chromosome organization
- growth plate cartilage development
- response to luteinizing hormone stimulus
- endochondral ossification
- limb morphogenesis
- chondrocyte proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cilium
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATP binding
- identical protein binding
- protein binding
- guanylate cyclase activity
- hormone binding
- peptide hormone binding
- protein kinase activity
- adenylate cyclase activity
- natriuretic peptide receptor activity