Bnc2 Gene Summary [Mouse]
Enables rDNA binding activity. Acts upstream of or within several processes, including endochondral bone growth; roof of mouth development; and tongue development. Located in chromatin and nucleus. Is expressed in several structures, including genitourinary system; jaw; nervous system; nose; and skin. Orthologous to human BNC2 (basonuclin zinc finger protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bnc2 |
| Official Name | basonuclin 2 [Source:MGI Symbol;Acc:MGI:2443805] |
| Ensembl ID | ENSMUSG00000028487 |
| Bio databases IDs | |
| Aliases | basonuclin 2 |
| Synonyms | 5031434M05RIK, 8430420F16Rik, basonuclin zinc finger protein 2, bn2, BSN2, LUTO |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bnc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
- ribosomal DNA (rDNA) binding protein
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- asthma
- chronic obstructive pulmonary disease
- cancer
- resistant hypertension
- liver cirrhosis
- metabolic syndrome X
- epithelial cancer
- inguinal hernia
- glaucoma
regulated by
- 4,5,6,7-tetrabromo-2-azabenzamidazole
- CC-885
- ESX1
- cantharidin
regulates
- COL1A1
- collagen alpha1
- collagen
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- nucleoplasm
- nuclear bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bnc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mesenchyme development
- endochondral bone growth
- palate development
- regulation of transcription, DNA-dependent
- tongue development
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- rDNA binding