Brca2 Gene Summary [Mouse]
Predicted to enable several functions, including gamma-tubulin binding activity; histone acetyltransferase activity; and identical protein binding activity. Involved in several processes, including establishment of protein localization to telomere; male meiosis I; and telomere maintenance via recombination. Acts upstream of or within several processes, including DNA metabolic process; hematopoietic stem cell proliferation; and signal transduction by p53 class mediator. Located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and hemolymphoid system gland. Used to study Fanconi anemia complementation group D1 and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); esophagus squamous cell carcinoma; hereditary breast ovarian cancer syndrome; melanoma (multiple); and reproductive organ cancer (multiple). Orthologous to human BRCA2 (BRCA2 DNA repair associated). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Brca2 |
| Official Name | breast cancer 2, early onset [Source:MGI Symbol;Acc:MGI:109337] |
| Ensembl ID | ENSMUSG00000041147 |
| Bio databases IDs | |
| Aliases | breast cancer 2, early onset |
| Synonyms | AW045498, BRCA2 DNA repair associated, BRCA2, DNA repair associated, BRCA3, BRCC2, breast cancer 2, early onset, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, RAB163, XRCC11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brca2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- transcription regulator
- histone acetyltransferase
- protease binding
- DNA binding domain
- RAD51 binding domain
- nuclear localization sequence
- transcription activation domain
- BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
- protein binding
- identical protein binding
- oligonucleotide/oligosaccharide-binding fold of replication protein A and class 2b aminoacyl-tRNA synthetases
- BRC repeat
- gamma-tubulin binding
- BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
- Tower
- BRCA2, helical
- single-stranded DNA binding
- BRCA2 repeat
- Cdk1-CyclinB-phosphorylation site
- delta-like domain
Pathways
Biological processes and signaling networks where the Brca2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- medulloblastoma
- mammary neoplasm
- colon cancer
- colorectal cancer
- organismal death
- hereditary cancer-predisposing syndrome
role in cell
- proliferation
- apoptosis
- phosphorylation in
- expression in
- number
- binding
- survival
- quantity
- binding in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- centrosome
- Flemming body
- cytosol
- nuclear foci
- chromosome
- nucleoplasm
- nuclear scaffolds
- secretory granules
- synaptonemal complexes
- telomeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brca2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to X-ray
- cellular senescence
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- nucleotide-excision repair
- female gonad development
- double-strand break repair
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- establishment of protein localization to telomere
- cellular response to ionizing radiation
- regulation of cytokinesis
- response to gamma radiation
- spermatogenesis
- male meiosis I
- double-strand break repair via homologous recombination
- regulation of transcription, DNA-dependent
- telomere maintenance via recombination
- brain development
- positive regulation of mitotic cell cycle
- oocyte maturation
- centrosome duplication
- inner cell mass cell proliferation
- hemopoietic stem cell proliferation
- response to UV-C
- regulation of DNA damage checkpoint
- negative regulation of mammary gland epithelial cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- centrosome
- nuclear ubiquitin ligase complex
- BRCA2-MAGE-D1 complex
- secretory granule
- cytosol
- lateral element
- macromolecular complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase activity
- H3 histone acetyltransferase activity
- identical protein binding
- protein binding
- gamma-tubulin binding
- protease binding
- H4 histone acetyltransferase activity
- single-stranded DNA binding