Lmo1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor binding activity and transcription coactivator activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; and regulation of T cell homeostatic proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human LMO1 (LIM domain only 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lmo1 |
| Official Name | LIM domain only 1 [Source:MGI Symbol;Acc:MGI:102812] |
| Ensembl ID | ENSMUSG00000036111 |
| Bio databases IDs | |
| Aliases | LIM domain only 1 |
| Synonyms | Dat1, LIM domain only 1, Lim only 1, RBTN1, RHOM1, Rhombotin, TTG1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lmo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- HER2 negative hormone receptor negative breast cancer
- neuroblastoma
- neuroblastoma formation
- T-lymphoblastic leukemia/lymphoma
- lymphomagenesis
- T acute lymphoblastic leukemia
- susceptibility to neuroblastoma type 7
- leukemogenesis
role in cell
- expression in
- proliferation
- growth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lmo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of T cell homeostatic proliferation
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- metal ion binding