Sgip1 Gene Summary [Mouse]
Enables microtubule binding activity and phospholipid binding activity. Involved in positive regulation of receptor-mediated endocytosis and synaptic vesicle endocytosis. Located in clathrin-coated vesicle and plasma membrane. Part of AP-2 adaptor complex. Is active in presynapse. Is expressed in central nervous system; genitourinary system; and small intestine. Orthologous to human SGIP1 (SH3GL interacting endocytic adaptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Sgip1 |
| Official Name | SH3-domain GRB2-like (endophilin) interacting protein 1 [Source:MGI Symbol;Acc:MGI:1920344] |
| Ensembl ID | ENSMUSG00000028524 |
| Bio databases IDs | |
| Aliases | SH3-domain GRB2-like (endophilin) interacting protein 1 |
| Synonyms | 3110007P09Rik, DKFZp761D221, gag, RGD1564957, SGIP1alpha, SH3-domain GRB2-like (endophilin) interacting protein 1, SH3GL interacting endocytic adaptor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sgip1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- microtubule binding
- tubulin binding
- AP_MHD_Cterm
- Muniscin C-terminal mu homology domain
- Mu-homology domain
- protein binding
- membrane phospholipid-binding domain
- SH3-domain binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- depressive disorder
- non-insulin-dependent diabetes mellitus
- COVID-19
- neuroblastoma
- neuroblastoma formation
- pain
- diabetic nephropathy
regulates
- TF
- EGF
role in cell
- endocytosis
- endocytosis by
- deformation in
- deformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- presynaptic regions
- intracellular space
- Plasma Membrane
- cytosol
- clathrin-coated pits
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sgip1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clathrin-mediated endocytosis
- energy homeostasis
- positive regulation of feeding behavior
- response to dietary excess
- positive regulation of receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- coated pit
- cytosol
- AP-2 adaptor complex
- clathrin-coated vesicle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH3 domain binding
- phospholipid binding
- microtubule binding