Arglu1 Gene Summary [Mouse]
Enables pre-mRNA binding activity and transcription coactivator activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and leg muscle. Orthologous to human ARGLU1 (arginine and glutamate rich 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arglu1 |
| Official Name | arginine and glutamate rich 1 [Source:MGI Symbol;Acc:MGI:2442985] |
| Ensembl ID | ENSMUSG00000040459 |
| Bio databases IDs | |
| Aliases | arginine and glutamate rich 1 |
| Synonyms | 9430010O03Rik, arginine and glutamate rich 1, C130008N12, RGD1310061 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arglu1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Arginine and glutamate-rich 1
- transcription co-activator
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- microcephaly
- non-small cell lung cancer
- productive infection by HIV-1
role in cell
- apoptosis
- cell cycle progression
- alternative splicing by
- alternative splicing in
- delocalization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arglu1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding