Trit1 Gene Summary [Mouse]
Enables tRNA dimethylallyltransferase activity. Involved in tRNA modification. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 35. Orthologous to human TRIT1 (tRNA isopentenyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trit1 |
| Official Name | tRNA isopentenyltransferase 1 [Source:MGI Symbol;Acc:MGI:1914216] |
| Ensembl ID | ENSMUSG00000028653 |
| Bio databases IDs | |
| Aliases | tRNA isopentenyltransferase 1 |
| Synonyms | 2310075G14Rik, COXPD35, GRO1, hGRO1, IPPT, IPT, IPTase, MOD5, tRNA isopentenyltransferase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trit1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IPP transferase
- tRNA dimethylallyltransferase
- Zinc-finger double-stranded RNA-binding
- U1 zinc finger
- enzyme
- protein binding
- tRNA isopentenyltransferase
- Non-methyl alkyl or aryl group transferase
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trit1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial tRNA modification
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- ATP binding
- zinc ion binding
- tRNA dimethylallyltransferase activity