Ndufs6 Gene Summary [Mouse]
Acts upstream of or within several processes, including DNA damage response, signal transduction by p53 class mediator; mesenchymal stem cell proliferation; and mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in limb; respiratory system; and skeleton. Used to study mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in cervical cancer and nuclear type mitochondrial complex I deficiency 9. Orthologous to human NDUFS6 (NADH:ubiquinone oxidoreductase subunit S6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufs6 |
| Official Name | NADH:ubiquinone oxidoreductase core subunit S6 [Source:MGI Symbol;Acc:MGI:107932] |
| Ensembl ID | ENSMUSG00000021606 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase core subunit S6 |
| Synonyms | BC059730, CI-13kA, CI-13kD-A, IP13, LOC100912599, MC1DN9, Nadh ubiquinone oxidoreductase 13 kda a subunit, NADH:ubiquinone oxidoreductase core subunit S6, NADH:ubiquinone oxidoreductase subunit S6, Ndufs6l1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ndufs6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- Zinc-finger domain
Pathways
Biological processes and signaling networks where the Ndufs6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- hereditary disorder
- chromophobe renal cell carcinoma
- chromophobe renal cancer
- nuclear type 9 mitochondrial complex I deficiency
- mitochondrial disorder
- Mitochondrial complex I deficiency
- fibrosis
- ischemic stroke
- lethal neonatal mitochondrial complex I deficiency
regulates
- reactive oxygen species
- adenosine triphosphate
- fatty acid
- Mitochondrial ETC 1
- hydroxyacylcarnitine
role in cell
- proliferation
- differentiation
- growth
- organization
- cell division
- abnormal morphology
- senescence in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ndufs6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- mitochondrial electron transport, NADH to ubiquinone
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- electron carrier activity
- NADH dehydrogenase (ubiquinone) activity