Mutyh Gene Summary [Mouse]
Predicted to enable DNA N-glycosylase activity; DNA binding activity; and MutSalpha complex binding activity. Involved in negative regulation of necroptotic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in familial adenomatous polyposis; familial adenomatous polyposis 2; stomach cancer; and stomach carcinoma. Orthologous to human MUTYH (mutY DNA glycosylase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mutyh |
| Official Name | mutY DNA glycosylase [Source:MGI Symbol;Acc:MGI:1917853] |
| Ensembl ID | ENSMUSG00000028687 |
| Bio databases IDs | |
| Aliases | mutY DNA glycosylase |
| Synonyms | 5730495A01Rik, mutY DNA glycosylase, Mutyha, Mutyhalpha, Mutyhb, Mutyhbeta, Mutyhc, MYH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mutyh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA N-glycosylase
- FES
- iron-sulfur cluster domain
- enzyme
- protein binding
- endonuclease III
- Helix-hairpin-helix motif
- A/G-specific adenine glycosylase
- HhH-GPD superfamily base excision DNA repair protein
- purine-specific mismatch base pair DNA N-glycosylase
- ENDO3c
- Iron-sulfur binding domain of endonuclease III
- binding protein
- NUDIX domain
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- adenoma formation
- epithelial neoplasia
- benign neoplasia
- epithelial cancer
- digestive system cancer
- abdominal cancer
- hereditary cancer-predisposing syndrome
- familial adenomatous polyposis type 2
regulates
- 8-hydroxyguanine
role in cell
- growth
- mutagenesis
- excitotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mutyh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- base-excision repair
- mismatch repair
- depurination
- negative regulation of necroptosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- adenine/guanine mispair binding
- purine-specific mismatch base pair DNA N-glycosylase activity
- MutSalpha complex binding
- MutSbeta complex binding
- MutLalpha complex binding
- protein binding
- MutLbeta complex binding
- metal ion binding
- 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
- DNA N-glycosylase activity
- 4 iron, 4 sulfur cluster binding
- oxidized purine DNA binding