Msh6 Gene Summary [Mouse]
Enables chromatin binding activity and damaged DNA binding activity. Contributes to guanine/thymine mispair binding activity. Acts upstream of or within several processes, including determination of adult lifespan; intrinsic apoptotic signaling pathway in response to DNA damage; and somatic diversification of immunoglobulins. Located in chromatin. Part of MutSalpha complex. Is expressed in several structures, including brain; early conceptus; liver; lung; and oocyte. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; hereditary nonpolyposis colorectal cancer type 5; and mismatch repair cancer syndrome. Orthologous to human MSH6 (mutS homolog 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Msh6 |
| Official Name | mutS homolog 6 [Source:MGI Symbol;Acc:MGI:1343961] |
| Ensembl ID | ENSMUSG00000005370 |
| Bio databases IDs | |
| Aliases | mutS homolog 6 |
| Synonyms | GTBP, GTMBP, hMSH6, HNPCC5, HSAP, LYNCH5, MMRCS3, mutS homolog 6, p160 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Msh6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- walker type B motif
- ADP binding
- ATPase domain of DNA mismatch repair MUTS family
- DNA secondary structure binding
- ATP binding
- protein binding activity, bridging
- PWWP domain
- chromatin binding
- enzyme
- Serine-rich region of AP3B1, clathrin-adaptor complex
- MutS domain II
- MutS domain I
- MutS domain III
- P-loop containing Nucleoside Triphosphate Hydrolases
- histone binding
- DNA mismatch repair protein MutS
- enzyme binding
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
- MutS domain V
- DNA dependent ATPase
- magnesium ion binding
- DNA binding
- binding protein
- damaged DNA binding
- double-stranded DNA binding
- MutS family domain IV
- DNA-binding domain of DNA mismatch repair MUTS family
Pathways
Biological processes and signaling networks where the Msh6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- digestive system cancer
- abdominal cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- hereditary cancer-predisposing syndrome
- gastric cancer
- Lynch syndrome
- epithelial endometrial cancer
role in cell
- apoptosis
- formation
- formation in
- survival
- quantity
- mutagenesis
- mono-ubiquitination in
- damage in
- hyperextension in
- colony survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- Golgi Apparatus
- cytosol
- nuclear foci
- nucleoplasm
- chromatin
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Msh6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- somatic recombination of immunoglobulin gene segments
- DNA repair
- determination of adult lifespan
- spermatogenesis
- positive regulation of helicase activity
- response to UV
- intrinsic apoptotic signaling pathway
- DNA damage response, signal transduction resulting in induction of apoptosis
- meiotic mismatch repair
- mismatch repair
- negative regulation of DNA recombination
- maintenance of DNA repeat elements
- somatic hypermutation of immunoglobulin genes
- isotype switching
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- MutSalpha complex
- cytosol
- Golgi apparatus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA-dependent ATPase activity
- protein homodimerization activity
- single guanine insertion binding
- single thymine insertion binding
- methylated histone residue binding
- double-stranded DNA binding
- ADP binding
- chromatin binding
- four-way junction DNA binding
- magnesium ion binding
- ATP binding
- MutLalpha complex binding
- protein binding
- mismatched DNA binding
- guanine/thymine mispair binding
- oxidized purine DNA binding
- enzyme binding