Hus1 Gene Summary [Mouse]
This gene encodes a component of a cell cycle checkpoint complex that causes cell cycle arrest in response to bulky DNA lesions and DNA replication blockage. Together with the proteins Rad9 and Rad1, the encoded protein forms a heterotrimeric complex known as the 9-1-1 complex. Mice lacking the encoded protein develop spontaneous chromosomal abnormalities resulting in embryonic lethality. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Details
| Type | Protein Coding |
| Official Symbol | Hus1 |
| Official Name | HUS1 checkpoint clamp component [Source:MGI Symbol;Acc:MGI:1277962] |
| Ensembl ID | ENSMUSG00000020413 |
| Bio databases IDs | |
| Aliases | HUS1 checkpoint clamp component |
| Synonyms | hHUS1, HUS1 checkpoint clamp component |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hus1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein binding
- Hus1-like protein
Pathways
Biological processes and signaling networks where the Hus1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- chorioallantoic membrane fusion failure
- Rett syndrome
role in cell
- expression in
- apoptosis
- cell death
- binding
- binding in
- damage
- DNA damage response
- breakage
- cohesion
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hus1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- embryo development ending in birth or egg hatching
- double-strand break repair via homologous recombination
- nucleotide-excision repair
- telomere maintenance
- response to UV
- response to DNA damage stimulus
- DNA damage checkpoint
- regulation of protein phosphorylation
- cellular response to ionizing radiation
- intra-S DNA damage checkpoint
- mitotic cell cycle DNA replication checkpoint
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- cytosol
- nucleolus
- nucleoplasm
- checkpoint clamp complex
Molecular Function
What the gene product does at the molecular level
- protein binding