Pef1 Gene Summary [Mouse]
Predicted to enable several functions, including calcium-dependent protein binding activity; protein heterodimerization activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including COPII vesicle coating; mesenchymal cell differentiation; and positive regulation of protein monoubiquitination. Predicted to be located in cytoplasm. Predicted to be part of COPII vesicle coat and Cul3-RING ubiquitin ligase complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human PEF1 (penta-EF-hand domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pef1 |
| Official Name | penta-EF hand domain containing 1 [Source:MGI Symbol;Acc:MGI:1915148] |
| Ensembl ID | ENSMUSG00000028779 |
| Bio databases IDs | |
| Aliases | penta-EF hand domain containing 1 |
| Synonyms | 2600002E23RIK, ABP32, PEF1A, Peflin, penta-EF-hand domain containing 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pef1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein dimerization
- calcium-dependent protein binding
- EF-hand, calcium binding motif
- EF-hand domain pair
- protein binding activity, bridging
- calcium ion binding
- EFh
- protein binding
- identical protein binding
- EF hand like domain
- EFh_PI-PLC
- The penta-EF hand (PEF) family
- EF-hand domain
- EF hand
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- cellular membrane
- Nucleus
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pef1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- neural crest cell development
- response to calcium ion
- neural crest formation
- COPII vesicle coating
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- endoplasmic reticulum
- Cul3-RING ubiquitin ligase complex
- COPII vesicle coat
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA binding
- protein heterodimerization activity
- calcium ion binding
- calcium-dependent protein binding
- protein dimerization activity