Ythdf2 Gene Summary [Mouse]
Enables N6-methyladenosine-containing RNA reader activity. Involved in several processes, including hematopoietic stem cell proliferation; negative regulation of gene expression; and spermatogonial cell division. Located in cytoplasm and nucleus. Is expressed in brain; intestine; and liver. Orthologous to human YTHDF2 (YTH N6-methyladenosine RNA binding protein F2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ythdf2 |
| Official Name | YTH N6-methyladenosine RNA binding protein 2 [Source:MGI Symbol;Acc:MGI:2444233] |
| Ensembl ID | ENSMUSG00000040025 |
| Bio databases IDs | |
| Aliases | YTH N6-methyladenosine RNA binding protein 2 |
| Synonyms | 9430020E02Rik, CAHL, DF2, HGRG8, KW4, NY-REN-2, YTH N6-methyladenosine RNA binding protein 2, YTH N6-methyladenosine RNA binding protein F2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ythdf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EVE and YTH domains belong to the PUA superfamily
- protein binding activity, bridging
- protein binding
- YT521-B-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- sepsis
- pulmonary hypertensive arterial disease
- tumorigenesis
- colorectal cancer
- lung adenocarcinoma
- cervical cancer
- glioblastoma
- glioblastoma cancer
- head and neck neoplasia
role in cell
- invasion by
- expression in
- degradation in
- apoptosis
- proliferation
- differentiation
- phosphorylation in
- growth
- adhesion
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- cytoplasmic mRNA processing body
- Nucleus
- centrosome
- cytosol
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ythdf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translational initiation
- stress granule assembly
- mRNA destabilization
- organelle assembly
- spermatogonial cell division
- negative regulation of type I interferon-mediated signaling pathway
- gamete generation
- regulation of mRNA stability
- negative regulation of Notch signaling pathway
- mRNA catabolic process
- oocyte maturation
- embryonic morphogenesis
- innate immune response
- negative regulation of stem cell differentiation
- humoral immune response
- hemopoietic stem cell proliferation
- regulation of rRNA processing
- regulation of cell adhesion
- regulation of neurogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytoplasm
- centriolar satellite
- cytoplasmic mRNA processing body
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- mRNA binding