Spag8 Gene Summary [Mouse]
Predicted to enable microtubule binding activity. Involved in flagellated sperm motility. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and male germ cell nucleus. Is active in axonemal A tubule inner sheath and sperm flagellum. Orthologous to human SPAG8 (sperm associated antigen 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spag8 |
| Official Name | sperm associated antigen 8 [Source:MGI Symbol;Acc:MGI:3056295] |
| Ensembl ID | ENSMUSG00000066196 |
| Bio databases IDs | |
| Aliases | sperm associated antigen 8 |
| Synonyms | BS-84, CILD28, CT142, HSD-1, hSMP-1, MH-SPAG8, SMP-1, SPAG3, sperm associated antigen 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spag8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- familial focal epilepsy with variable foci type 2
- Maroteaux type acromesomelic dysplasia
- colorectal cancer
- short stature with nonspecific skeletal abnormalities
regulated by
- SNCA
- clofutriben
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- Nucleus
- axonemes
- cytosol
- nucleoplasm
- sperm tail
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spag8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- single fertilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- axonemal microtubule
- microtubule organizing center
- cytoplasm
- acrosomal vesicle
- membrane
- spindle
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding