Hpca Gene Summary [Mouse]
Predicted to enable several functions, including actin binding activity; calcium ion binding activity; and identical protein binding activity. Acts upstream of or within inner ear development. Predicted to be located in several cellular components, including dendrite; neuronal cell body membrane; and perikaryon. Predicted to be active in glutamatergic synapse and postsynapse. Is expressed in ganglia; salivary gland primordium; and telencephalon. Human ortholog(s) of this gene implicated in torsion dystonia 2. Orthologous to human HPCA (hippocalcin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hpca |
| Official Name | hippocalcin [Source:MGI Symbol;Acc:MGI:1336200] |
| Ensembl ID | ENSMUSG00000028785 |
| Bio databases IDs | |
| Aliases | hippocalcin |
| Synonyms | BDR2, DYT2, HIPPOCALCIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hpca often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- kinase binding
- EF-hand domain pair
- actin binding
- EF hand
- calcium ion binding
- EFh
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- dystonia mysculorum deformans 2
regulates
- phospholipase
role in cell
- apoptosis
- response by
- excitotoxicity
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- cellular membrane
- Nucleus
- cytosol
- dendritic spine head
- synaptic vesicles
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hpca gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear development
- positive regulation of protein targeting to membrane
- cellular response to calcium ion
- retina development in camera-type eye
- cellular response to electrical stimulus
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- dendrite membrane
- cytoplasm
- dendrite cytoplasm
- membrane
- cytosol
- neuronal cell body membrane
- perikaryon
- axon
- dendritic spine head
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- actin binding
- calcium ion binding
- kinase binding