Vsnl1 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Acts upstream of or within negative regulation of insulin secretion; positive regulation of exocytosis; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in cytosol and membrane. Is expressed in several structures, including alimentary system; brain; great vessel of heart; heart; and sensory organ. Orthologous to human VSNL1 (visinin like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vsnl1 |
| Official Name | visinin-like 1 [Source:MGI Symbol;Acc:MGI:1349453] |
| Ensembl ID | ENSMUSG00000054459 |
| Bio databases IDs | |
| Aliases | visinin-like 1 |
| Synonyms | HLP3, HPCAL3, HUVISL1, Nvp-1, Ratnvp1, VILIP, VILIP-1, visinin-like 1, Vnsl1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vsnl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- Dockerin type I domain
- EF-hand domain pair
- EF hand
- calcium ion binding
- EFh
- protein binding
- EFh_PI-PLC
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- coronary artery disease
- schizophrenia
- glioblastoma
- glioblastoma cancer
- ischemic stroke
- psoriasis
- psychosis
- lung squamous cell carcinoma
- squamous cell lung cancer
role in cell
- apoptosis
- migration
- adhesion
- exocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cellular membrane
- cytosol
- clathrin-coated vesicles
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vsnl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of insulin secretion
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- positive regulation of exocytosis
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding