Ncald Gene Summary [Mouse]
Predicted to enable calcium ion binding activity; clathrin binding activity; and cytoskeletal protein binding activity. Acts upstream of or within calcium-mediated signaling and regulation of systemic arterial blood pressure. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human NCALD (neurocalcin delta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncald |
| Official Name | neurocalcin delta [Source:MGI Symbol;Acc:MGI:1196326] |
| Ensembl ID | ENSMUSG00000051359 |
| Bio databases IDs | |
| Aliases | neurocalcin delta |
| Synonyms | D030020D09Rik, D15ERTD412E, neurocalcin delta, neurocalcin δ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncald often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- tubulin binding
- EF-hand domain pair
- actin binding
- EF hand
- alpha-tubulin binding
- clathrin binding
- EFh
- protein binding
- EFh_PI-PLC
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- pervasive developmental disorder
- COVID-19
- chronic obstructive pulmonary disease
- venous thromboembolism
- coronary artery disease
- microalbuminuria
- alcoholism
- major depression
- cerebral amyloid angiopathy
regulates
- MGC
- GUCY2D
role in cell
- migration
- invasion by
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- membrane fraction
- cytosol
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncald gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- regulation of systemic arterial blood pressure
- calcium-mediated signaling
Cellular Component
Where in the cell the gene product is active
- clathrin coat of trans-Golgi network vesicle
- cytosol
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein binding
- actin binding
- calcium ion binding
- alpha-tubulin binding
- clathrin binding