Dtx2 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within Notch signaling pathway. Predicted to be located in nuclear membrane. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; brain; gonad; nasal cavity epithelium; and pharyngo-tympanic tube. Orthologous to human DTX2 (deltex E3 ubiquitin ligase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dtx2 |
| Official Name | deltex 2, E3 ubiquitin ligase [Source:MGI Symbol;Acc:MGI:1921448] |
| Ensembl ID | ENSMUSG00000004947 |
| Bio databases IDs | |
| Aliases | deltex 2, E3 ubiquitin ligase |
| Synonyms | 2610524D08Rik, Deltex2, deltex 2, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 2, LOC100653244, LOC101930424, RNF58 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dtx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in Deltex and TRIP12 homologues
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- WWE domain
- protein binding
- Domain found at the C-terminus of deltex-like
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Dtx2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- psoriasis
- organismal death
- low-grade glioma
- glioma formation
- glioblastoma
- glioblastoma cancer
- glioma
- plexiform neurofibroma
role in cell
- growth
- ubiquitination in
- replication in
- migration
- cell viability
- formation
- colony formation by
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dtx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding